Gut microbiota are related to Parkinson's disease and clinical phenotype.
Identifieur interne : 000221 ( Main/Exploration ); précédent : 000220; suivant : 000222Gut microbiota are related to Parkinson's disease and clinical phenotype.
Auteurs : Filip Scheperjans [Finlande] ; Velma Aho ; Pedro A B. Pereira ; Kaisa Koskinen ; Lars Paulin ; Eero Pekkonen ; Elena Haapaniemi ; Seppo Kaakkola ; Johanna Eerola-Rautio ; Marjatta Pohja ; Esko Kinnunen ; Kari Murros ; Petri AuvinenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and parasympathetic nerves are amongst the structures earliest and most frequently affected by alpha-synuclein pathology. Accordingly, gastrointestinal dysfunction, in particular constipation, is an important non-motor symptom in PD and often precedes the onset of motor symptoms by years. Recent research has shown that intestinal microbiota interact with the autonomic and central nervous system via diverse pathways including the ENS and vagal nerve. The gut microbiome in PD has not been previously investigated. We compared the fecal microbiomes of 72 PD patients and 72 control subjects by pyrosequencing the V1-V3 regions of the bacterial 16S ribosomal RNA gene. Associations between clinical parameters and microbiota were analyzed using generalized linear models, taking into account potential confounders. On average, the abundance of Prevotellaceae in feces of PD patients was reduced by 77.6% as compared with controls. Relative abundance of Prevotellaceae of 6.5% or less had 86.1% sensitivity and 38.9% specificity for PD. A logistic regression classifier based on the abundance of four bacterial families and the severity of constipation identified PD patients with 66.7% sensitivity and 90.3% specificity. The relative abundance of Enterobacteriaceae was positively associated with the severity of postural instability and gait difficulty. These findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype. Further studies are warranted to elucidate the temporal and causal relationships between gut microbiota and PD and the suitability of the microbiome as a biomarker.
DOI: 10.1002/mds.26069
PubMed: 25476529
Affiliations:
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Pereira</name></author><author><name sortKey="Koskinen, Kaisa" sort="Koskinen, Kaisa" uniqKey="Koskinen K" first="Kaisa" last="Koskinen">Kaisa Koskinen</name></author><author><name sortKey="Paulin, Lars" sort="Paulin, Lars" uniqKey="Paulin L" first="Lars" last="Paulin">Lars Paulin</name></author><author><name sortKey="Pekkonen, Eero" sort="Pekkonen, Eero" uniqKey="Pekkonen E" first="Eero" last="Pekkonen">Eero Pekkonen</name></author><author><name sortKey="Haapaniemi, Elena" sort="Haapaniemi, Elena" uniqKey="Haapaniemi E" first="Elena" last="Haapaniemi">Elena Haapaniemi</name></author><author><name sortKey="Kaakkola, Seppo" sort="Kaakkola, Seppo" uniqKey="Kaakkola S" first="Seppo" last="Kaakkola">Seppo Kaakkola</name></author><author><name sortKey="Eerola Rautio, Johanna" sort="Eerola Rautio, Johanna" uniqKey="Eerola Rautio J" first="Johanna" last="Eerola-Rautio">Johanna Eerola-Rautio</name></author><author><name sortKey="Pohja, Marjatta" sort="Pohja, Marjatta" uniqKey="Pohja M" first="Marjatta" last="Pohja">Marjatta Pohja</name></author><author><name sortKey="Kinnunen, Esko" sort="Kinnunen, Esko" uniqKey="Kinnunen E" first="Esko" last="Kinnunen">Esko Kinnunen</name></author><author><name sortKey="Murros, Kari" sort="Murros, Kari" uniqKey="Murros K" first="Kari" last="Murros">Kari Murros</name></author><author><name sortKey="Auvinen, Petri" sort="Auvinen, Petri" uniqKey="Auvinen P" first="Petri" last="Auvinen">Petri Auvinen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25476529</idno><idno type="pmid">25476529</idno><idno type="doi">10.1002/mds.26069</idno><idno type="wicri:Area/PubMed/Corpus">000330</idno><idno type="wicri:Area/PubMed/Curation">000330</idno><idno type="wicri:Area/PubMed/Checkpoint">000221</idno><idno type="wicri:Area/Ncbi/Merge">004179</idno><idno type="wicri:Area/Ncbi/Curation">004179</idno><idno type="wicri:Area/Ncbi/Checkpoint">004179</idno><idno type="wicri:Area/Main/Merge">000221</idno><idno type="wicri:Area/Main/Curation">000221</idno><idno type="wicri:Area/Main/Exploration">000221</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gut microbiota are related to Parkinson's disease and clinical phenotype.</title><author><name sortKey="Scheperjans, Filip" sort="Scheperjans, Filip" uniqKey="Scheperjans F" first="Filip" last="Scheperjans">Filip Scheperjans</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Helsinki University Central Hospital, and Department of Neurological Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Helsinki University Central Hospital, and Department of Neurological Sciences, University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Aho, Velma" sort="Aho, Velma" uniqKey="Aho V" first="Velma" last="Aho">Velma Aho</name></author><author><name sortKey="Pereira, Pedro A B" sort="Pereira, Pedro A B" uniqKey="Pereira P" first="Pedro A B" last="Pereira">Pedro A B. Pereira</name></author><author><name sortKey="Koskinen, Kaisa" sort="Koskinen, Kaisa" uniqKey="Koskinen K" first="Kaisa" last="Koskinen">Kaisa Koskinen</name></author><author><name sortKey="Paulin, Lars" sort="Paulin, Lars" uniqKey="Paulin L" first="Lars" last="Paulin">Lars Paulin</name></author><author><name sortKey="Pekkonen, Eero" sort="Pekkonen, Eero" uniqKey="Pekkonen E" first="Eero" last="Pekkonen">Eero Pekkonen</name></author><author><name sortKey="Haapaniemi, Elena" sort="Haapaniemi, Elena" uniqKey="Haapaniemi E" first="Elena" last="Haapaniemi">Elena Haapaniemi</name></author><author><name sortKey="Kaakkola, Seppo" sort="Kaakkola, Seppo" uniqKey="Kaakkola S" first="Seppo" last="Kaakkola">Seppo Kaakkola</name></author><author><name sortKey="Eerola Rautio, Johanna" sort="Eerola Rautio, Johanna" uniqKey="Eerola Rautio J" first="Johanna" last="Eerola-Rautio">Johanna Eerola-Rautio</name></author><author><name sortKey="Pohja, Marjatta" sort="Pohja, Marjatta" uniqKey="Pohja M" first="Marjatta" last="Pohja">Marjatta Pohja</name></author><author><name sortKey="Kinnunen, Esko" sort="Kinnunen, Esko" uniqKey="Kinnunen E" first="Esko" last="Kinnunen">Esko Kinnunen</name></author><author><name sortKey="Murros, Kari" sort="Murros, Kari" uniqKey="Murros K" first="Kari" last="Murros">Kari Murros</name></author><author><name sortKey="Auvinen, Petri" sort="Auvinen, Petri" uniqKey="Auvinen P" first="Petri" last="Auvinen">Petri Auvinen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and parasympathetic nerves are amongst the structures earliest and most frequently affected by alpha-synuclein pathology. Accordingly, gastrointestinal dysfunction, in particular constipation, is an important non-motor symptom in PD and often precedes the onset of motor symptoms by years. Recent research has shown that intestinal microbiota interact with the autonomic and central nervous system via diverse pathways including the ENS and vagal nerve. The gut microbiome in PD has not been previously investigated. We compared the fecal microbiomes of 72 PD patients and 72 control subjects by pyrosequencing the V1-V3 regions of the bacterial 16S ribosomal RNA gene. Associations between clinical parameters and microbiota were analyzed using generalized linear models, taking into account potential confounders. On average, the abundance of Prevotellaceae in feces of PD patients was reduced by 77.6% as compared with controls. Relative abundance of Prevotellaceae of 6.5% or less had 86.1% sensitivity and 38.9% specificity for PD. A logistic regression classifier based on the abundance of four bacterial families and the severity of constipation identified PD patients with 66.7% sensitivity and 90.3% specificity. The relative abundance of Enterobacteriaceae was positively associated with the severity of postural instability and gait difficulty. These findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype. Further studies are warranted to elucidate the temporal and causal relationships between gut microbiota and PD and the suitability of the microbiome as a biomarker.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Aho, Velma" sort="Aho, Velma" uniqKey="Aho V" first="Velma" last="Aho">Velma Aho</name><name sortKey="Auvinen, Petri" sort="Auvinen, Petri" uniqKey="Auvinen P" first="Petri" last="Auvinen">Petri Auvinen</name><name sortKey="Eerola Rautio, Johanna" sort="Eerola Rautio, Johanna" uniqKey="Eerola Rautio J" first="Johanna" last="Eerola-Rautio">Johanna Eerola-Rautio</name><name sortKey="Haapaniemi, Elena" sort="Haapaniemi, Elena" uniqKey="Haapaniemi E" first="Elena" last="Haapaniemi">Elena Haapaniemi</name><name sortKey="Kaakkola, Seppo" sort="Kaakkola, Seppo" uniqKey="Kaakkola S" first="Seppo" last="Kaakkola">Seppo Kaakkola</name><name sortKey="Kinnunen, Esko" sort="Kinnunen, Esko" uniqKey="Kinnunen E" first="Esko" last="Kinnunen">Esko Kinnunen</name><name sortKey="Koskinen, Kaisa" sort="Koskinen, Kaisa" uniqKey="Koskinen K" first="Kaisa" last="Koskinen">Kaisa Koskinen</name><name sortKey="Murros, Kari" sort="Murros, Kari" uniqKey="Murros K" first="Kari" last="Murros">Kari Murros</name><name sortKey="Paulin, Lars" sort="Paulin, Lars" uniqKey="Paulin L" first="Lars" last="Paulin">Lars Paulin</name><name sortKey="Pekkonen, Eero" sort="Pekkonen, Eero" uniqKey="Pekkonen E" first="Eero" last="Pekkonen">Eero Pekkonen</name><name sortKey="Pereira, Pedro A B" sort="Pereira, Pedro A B" uniqKey="Pereira P" first="Pedro A B" last="Pereira">Pedro A B. Pereira</name><name sortKey="Pohja, Marjatta" sort="Pohja, Marjatta" uniqKey="Pohja M" first="Marjatta" last="Pohja">Marjatta Pohja</name></noCountry><country name="Finlande"><noRegion><name sortKey="Scheperjans, Filip" sort="Scheperjans, Filip" uniqKey="Scheperjans F" first="Filip" last="Scheperjans">Filip Scheperjans</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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